Ontology highlight
ABSTRACT:
SUBMITTER: Saglık BN
PROVIDER: S-EPMC7821958 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Sağlık Begüm Nurpelin BN Osmaniye Derya D Acar Çevik Ulviye U Levent Serkan S Kaya Çavuşoğlu Betül B Atlı Eklioğlu Özlem Ö Özkay Yusuf Y Koparal Ali Savaş AS Kaplancıklı Zafer Asım ZA
Journal of enzyme inhibition and medicinal chemistry 20201201 1
Many studies have been conducted on the selective inhibition of human monoamine oxidase B (<i>h</i>MAO-B) enzyme using benzylamine-sulphonamide derivatives. Using various chemical modifications on <b>BB-4h</b>, which was reported previously by our team and showed a significant level of MAO-B inhibition, novel benzylamine-sulphonamide derivatives were designed, synthesised, and their MAO inhibition potentials were evaluated. Among the tested derivatives, compounds <b>4i</b> and <b>4t</b> achieved ...[more]