Effects of rotavirus NSP4 protein on the immune response and protection of the S_R69A-VP8* nanoparticle rotavirus vaccine.

ABSTRACT: Rotavirus causes severe diarrhea and dehydration in young children. Even with the implementation of the current live vaccines, rotavirus infections still cause significant mortality and morbidity, indicating a need for new rotavirus vaccines with improved efficacy. To this end, we have developed an S_R69A-VP8*/S₆₀-VP8* nanoparticle rotavirus vaccine candidate that will be delivered parenterally with Alum adjuvant. In this study, as parts of our further development of this nanoparticle vaccine, we evaluated 1) roles of rotavirus nonstructural protein 4 (NSP4) that is the rotavirus enterotoxin, a possible vaccine target, and an immune stimulator, and 2) effects of CpG adjuvant that is a toll-like receptor 9 (TLR9) ligand and agonist on the immune response and protection

SUBMITTER: Liu C 

PROVIDER: S-EPMC7822095 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature