Ontology highlight
ABSTRACT:
SUBMITTER: Tay H
PROVIDER: S-EPMC7822194 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Tay Hanna H Du Cheyne Charis C Demeyere Kristel K De Craene Jurgen J De Bels Lobke L Meyer Evelyne E Zijlstra Andries A Spiegelaere Ward De W
Cells 20201222 1
Macrophages play an important but poorly understood role in angiogenesis. To investigate their role in vessel formation, relevant in vivo models are crucial. Although the chick chorioallantoic membrane (CAM) model has been frequently used as an angiogenesis assay, limited data are available on the involvement of chicken macrophages in this process. Here, we describe a method to deplete macrophages in the ex ovo chick CAM assay by injection of clodronate liposomes and show that this depletion dir ...[more]