Ontology highlight
ABSTRACT:
SUBMITTER: Andersson R
PROVIDER: S-EPMC7822560 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Andersson Rebecca R Eisele-Bürger Anna Maria AM Hanzén Sarah S Vielfort Katarina K Öling David D Eisele Frederik F Johansson Gustav G Gustafsson Tobias T Kvint Kristian K Nyström Thomas T
PLoS genetics 20210111 1
70 kDa heat shock proteins (Hsp70) are essential chaperones of the protein quality control network; vital for cellular fitness and longevity. The four cytosolic Hsp70's in yeast, Ssa1-4, are thought to be functionally redundant but the absence of Ssa1 and Ssa2 causes a severe reduction in cellular reproduction and accelerates replicative aging. In our efforts to identify which Hsp70 activities are most important for longevity assurance, we systematically investigated the capacity of Ssa4 to carr ...[more]