Ontology highlight
ABSTRACT:
SUBMITTER: Balbach M
PROVIDER: S-EPMC7822642 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Balbach Melanie M Gervasi Maria Gracia MG Hidalgo David Martin DM Visconti Pablo E PE Levin Lonny R LR Buck Jochen J
Biology of reproduction 20201001 4
Mammalian sperm are stored in the epididymis in a dormant state. Upon ejaculation, they must immediately start producing sufficient energy to maintain motility and support capacitation. While this increased energy demand during capacitation is well established, it remains unclear how mouse sperm modify their metabolism to meet this need. We now show that capacitating mouse sperm enhance glucose uptake, identifying glucose uptake as a functional marker of capacitation. Using an extracellular flux ...[more]