Tissue Failure Propagation as Mediated by Circulatory Flow.
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ABSTRACT:
SUBMITTER: Uppal G
PROVIDER: S-EPMC7822750 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Tissue Failure Propagation as Mediated by Circulatory Flow.
Uppal Gurdip G Bahcecioglu Gokhan G Zorlutuna Pinar P Vural Dervis Can DC
Biophysical journal 20201113 12
Aging is driven by subcellular processes that are relatively well understood. However, the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade to a macro-level catastrophe in a tissue or organs remain largely unexplored. Here, we experimentally and theoretically study how cell failure propagates in an engineered tissue in the presence of advective flow. We argue that cells secrete cooperative factors, thereby forming a network of interdependence governed by ...[more]
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