Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7822816 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wang Ying Y Li Jiazhuo J Zhou Zhiwei Z Zhou Ronghui R Sun Qun Q Wu Peng P
Nature communications 20210122 1
Aciduric bacteria that can survive in extremely acidic conditions (pH < 4.0) are challenging to the current antimicrobial approaches, including antibiotics and photodynamic bacteria inactivation (PDI). Here, we communicate a photosensitizer design concept of halogenation of fluorescein for extremely acidic PDI. Upon halogenation, the well-known spirocyclization that controls the absorption of fluorescein shifts to the acidic pH range. Meanwhile, the heavy atom effect of halogens boosts the gener ...[more]