Ontology highlight
ABSTRACT:
SUBMITTER: Cohain AT
PROVIDER: S-EPMC7822923 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cohain Ariella T AT Barrington William T WT Jordan Daniel M DM Beckmann Noam D ND Argmann Carmen A CA Houten Sander M SM Charney Alexander W AW Ermel Raili R Sukhavasi Katyayani K Franzen Oscar O Koplev Simon S Whatling Carl C Belbin Gillian M GM Yang Jialiang J Hao Ke K Kenny Eimear E EE Tu Zhidong Z Zhu Jun J Gan Li-Ming LM Do Ron R Giannarelli Chiara C Kovacic Jason C JC Ruusalepp Arno A Lusis Aldons J AJ Bjorkegren Johan L M JLM Schadt Eric E EE
Nature communications 20210122 1
Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk. We explore the relationship between lipid and glucose control by constructing network models from the STARNET study with sequencing data from seven cardiometabolic tissues obtained from CAD patients during coronary artery by-pass grafting surgery. B ...[more]