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Deubiquitylating enzymes in neuronal health and disease.

ABSTRACT: Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.

SUBMITTER: Amer-Sarsour F

PROVIDER: S-EPMC7822931 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Deubiquitylating enzymes in neuronal health and disease.

Amer-Sarsour Fatima F Kordonsky Alina A Berdichevsky Yevgeny Y Prag Gali G Ashkenazi Avraham A

Cell death & disease 20210122 1

Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease. ...[more]

PMID: 33483467

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