Conventional ICSI improves the euploid embryo rate in male reciprocal translocation carriers.

ABSTRACT:

Purpose

To evaluate whether the morphologically normal spermatozoa selected for intracytoplasmic sperm injection (ICSI) under microscope had a higher rate of normal/balanced chromosome contents than that in the whole unselected sperm from reciprocal translocation carriers.

Methods

Five hundred unselected spermatozoa from each of 40 male translocation carriers were performed with fluorescence in situ hybridization (FISH), to determine the rates of gametes with different meiotic contents of translocated chromosomes. Meanwhile, 3030 biopsied blastocysts from 239 male and 293 female reciprocal translocation carriers were detected with the microarray technique to analyze the rates of embryos with different translocated chromosome contents.

Results

The D3 embryo rate, blast

SUBMITTER: Lei C 

PROVIDER: S-EPMC7822975 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature