Ontology highlight
ABSTRACT:
SUBMITTER: Burke SJ
PROVIDER: S-EPMC7823448 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Burke Susan J SJ Taylor Jessica L JL Batdorf Heidi M HM Noland Robert C RC Burk David H DH Yu Yongmei Y Floyd Z Elizabeth ZE Collier J Jason JJ
Biomedicines 20201230 1
Glucocorticoids are clinically essential drugs used routinely to control inflammation. However, a host of metabolic side effects manifests upon usage beyond a few days. In the present study, we tested the hypothesis that seven-in-absentia mammalian homolog-2 (SIAH2), a ubiquitin ligase that regulates adipogenesis, is important for controlling adipocyte size, inflammation, and the ability of adipose tissue to expand in response to a glucocorticoid challenge. Using mice with global deletion of SIA ...[more]