RAB11-Mediated Trafficking and Human Cancers: An Updated Review.
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ABSTRACT:
SUBMITTER: Ferro E
PROVIDER: S-EPMC7823896 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
RAB11-Mediated Trafficking and Human Cancers: An Updated Review.
Ferro Elsi E Bosia Carla C Campa Carlo C CC
Biology 20210104 1
Many disorders block and subvert basic cellular processes in order to boost their progression. One protein family that is prone to be altered in human cancers is the small GTPase RAB11 family, the master regulator of vesicular trafficking. RAB11 isoforms function as membrane organizers connecting the transport of cargoes towards the plasma membrane with the assembly of autophagic precursors and the generation of cellular protrusions. These processes dramatically impact normal cell physiology and ...[more]
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