Ontology highlight
ABSTRACT:
SUBMITTER: Pellegrino M
PROVIDER: S-EPMC7824126 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Cells 20201224 1
The adoptive transfer of the chimeric antigen receptor (CAR) expressing T-cells has produced unprecedented successful results in the treatment of B-cell malignancies. However, the use of this technology in other malignancies remains less effective. In the setting of solid neoplasms, CAR T-cell metabolic fitness needs to be optimal to reach the tumor and execute their cytolytic function in an environment often hostile. It is now well established that both tumor and T cell metabolisms play critica ...[more]