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The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19.

ABSTRACT: The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitro studies and the clinic that apilimod blocks antiviral immune responses. We therefore warn that the immunosuppression observed in many COVID-19 patients might be aggravated by apilimod.

SUBMITTER: Baranov MV

PROVIDER: S-EPMC7824419 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19.

Baranov Maksim V MV Bianchi Frans F van den Bogaart Geert G

Cells 20201227 1

The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitro studies and the clinic that apilimod blocks antiviral immune responses. We therefore warn that the immunosuppression observed in many COVID-19 patients might be aggravated by apil ...[more]

PMID: 33375410

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