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Novel Macrolactams from a Deep-Sea-Derived Streptomyces Species.

ABSTRACT: Four polyene macrolactams including the previously reported niizalactam C (4), and three new ones, streptolactams A-C (1-3) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived Streptomyces sp. OUCMDZ-3159. Their structures were determined based on spectroscopic analysis, X-ray diffraction analysis, and chemical methods. The abiotic formation of compounds 2 and 4 from compound 1 were confirmed by a series of chemical reactions under heat and light conditions. Compounds 1 and 3 showed a selective antifungal activity against Candida albicans ATCC 10231.

SUBMITTER: Wang P

PROVIDER: S-EPMC7824713 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Novel Macrolactams from a Deep-Sea-Derived Streptomyces Species.

Wang Pei P Wang Dongyang D Zhang Rongxin R Wang Yi Y Kong Fandong F Fu Peng P Zhu Weiming W

Marine drugs 20201229 1

Four polyene macrolactams including the previously reported niizalactam C (4), and three new ones, streptolactams A-C (1-3) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived Streptomyces sp. OUCMDZ-3159. Their structures were determined based on spectroscopic analysis, X-ray diffraction analysis, and chemical methods. The ...[more]

PMID: 33383849

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