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Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers.

ABSTRACT: Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide. Recent advances in recombinant DNA technology have led to the development of numerous therapeutic antibodies as major sources of blockbuster drugs for CRC therapy. Simultaneously, increasing numbers of therapeutic targets in CRC have been identified. In this review, we first highlight the physiological and pathophysiological roles and signaling mechanisms of currently known and emerging therapeutic targets, including growth factors and their receptors as well as immune checkpoint proteins, in CRC. Additionally, we discuss the current status of monoclonal antibodies in clinical development and approved by US Food and Drug Administration for CRC therapy.

SUBMITTER: Hwang K 

PROVIDER: S-EPMC7824816 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers.

Hwang Kyusang K   Yoon Jin Hwan JH   Lee Ji Hyun JH   Lee Sukmook S  

Biomedicines 20210105 1

Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide. Recent advances in recombinant DNA technology have led to the development of numerous therapeutic antibodies as major sources of blockbuster drugs for CRC therapy. Simultaneously, increasing numbers of therapeutic targets in CRC have been identified. In this review, we first highlight the physiological and pathophysiological roles and signaling mechanisms of currently known and emerging therapeutic targets, includin  ...[more]

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