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Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario.


ABSTRACT:

Background

Recent studies are lacking reports on mortality after non-hip fractures in adults aged >?65.

Methods

This retrospective, matched-cohort study used de-identified health services data from the publicly funded healthcare system in Ontario, Canada, contained in the ICES Data Repository. Patients aged 66?years and older with an index fragility fracture occurring at any osteoporotic site between 2011 and 2015 were identified from acute hospital admissions, emergency and ambulatory care using International Classification of Diseases (ICD)-10 codes and data were analyzed until 2017. Thus, follow-up ranged from 2?years to 6?years. Patients were excluded if they presented with an index fracture occurring at a non-osteoporotic fracture site, their index fracture was associated with a trauma code, or they experienced a previous fracture within 5?years prior to their index fracture. This fracture cohort was matched 1:1 to controls within a non-fracture cohort by date, sex, age, geography and comorbidities. All-cause mortality risk was assessed.

Results

The survival probability for up to 6?years post-fracture was significantly reduced for the fracture cohort vs matched non-fracture controls (p ConclusionsIn this real-world cohort aged >?65?years, a fragility fracture occurring at any site was associated with reduced survival for up to 6?years post-fracture. The greatest reduction in survival occurred within the first-year post-fracture, where mortality risk more than doubled and deaths were observed in 1 in 11 women and 1 in 7 men following a non-hip fracture and in 1 in 5 women and 1 in 3 men following a hip fracture.

SUBMITTER: Brown JP 

PROVIDER: S-EPMC7824940 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario.

Brown Jacques P JP   Adachi Jonathan D JD   Schemitsch Emil E   Tarride Jean-Eric JE   Brown Vivien V   Bell Alan A   Reiner Maureen M   Oliveira Thiago T   Motsepe-Ditshego Ponda P   Burke Natasha N   Slatkovska Lubomira L  

BMC musculoskeletal disorders 20210123 1


<h4>Background</h4>Recent studies are lacking reports on mortality after non-hip fractures in adults aged > 65.<h4>Methods</h4>This retrospective, matched-cohort study used de-identified health services data from the publicly funded healthcare system in Ontario, Canada, contained in the ICES Data Repository. Patients aged 66 years and older with an index fragility fracture occurring at any osteoporotic site between 2011 and 2015 were identified from acute hospital admissions, emergency and ambul  ...[more]

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