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Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.


ABSTRACT: Mutation and recombination are the primary sources of genetic variation. To better understand the evolution of genetic variation, it is crucial to comprehensively investigate the processes involving mutation accumulation and recombination. In this study, we performed mutation accumulation experiments on four heterozygous diploid yeast species in the Saccharomycodaceae family to determine spontaneous mutation rates, mutation spectra, and losses of heterozygosity (LOH). We observed substantial variation in mutation rates and mutation spectra. We also observed high LOH rates (1.65-11.07×10-6 events per heterozygous site per cell division). Biases in spontaneous mutation and LOH together with selection ultimately shape the variable genome-wide nucleotide landscape in yeast species.

SUBMITTER: Nguyen DT 

PROVIDER: S-EPMC7825102 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.

Nguyen Duong T DT   Wu Baojun B   Long Hongan H   Zhang Nan N   Patterson Caitlyn C   Simpson Stephen S   Morris Krystalynne K   Thomas W Kelley WK   Lynch Michael M   Hao Weilong W  

Molecular biology and evolution 20201101 11


Mutation and recombination are the primary sources of genetic variation. To better understand the evolution of genetic variation, it is crucial to comprehensively investigate the processes involving mutation accumulation and recombination. In this study, we performed mutation accumulation experiments on four heterozygous diploid yeast species in the Saccharomycodaceae family to determine spontaneous mutation rates, mutation spectra, and losses of heterozygosity (LOH). We observed substantial var  ...[more]

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