Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.
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ABSTRACT:
SUBMITTER: Nguyen DT
PROVIDER: S-EPMC7825102 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.
Nguyen Duong T DT Wu Baojun B Long Hongan H Zhang Nan N Patterson Caitlyn C Simpson Stephen S Morris Krystalynne K Thomas W Kelley WK Lynch Michael M Hao Weilong W
Molecular biology and evolution 20201101 11
Mutation and recombination are the primary sources of genetic variation. To better understand the evolution of genetic variation, it is crucial to comprehensively investigate the processes involving mutation accumulation and recombination. In this study, we performed mutation accumulation experiments on four heterozygous diploid yeast species in the Saccharomycodaceae family to determine spontaneous mutation rates, mutation spectra, and losses of heterozygosity (LOH). We observed substantial var ...[more]
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