Ontology highlight
ABSTRACT:
SUBMITTER: Ho LC
PROVIDER: S-EPMC7825677 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Ho Li-Chun LC Wu Ting-Yun TY Lin Tsun-Mei TM Liou Hung-Hsiang HH Hung Shih-Yuan SY
Toxins 20210107 1
The NLRP3 inflammasome is responsible for the maturation of caspase-1 and interleukin-1β (IL-1β). Despite the study about basal activity of the NLRP3 inflammasome in hemodialysis (HD) patients, little is known about its inducibility in the milieu of uremia. Peripheral blood mononuclear cells (PBMCs) isolated from 11 HD patients and 14 volunteers without a history of chronic kidney disease, as well as macrophages with or without the uremic toxin indoxyl sulfate (IS) pretreatment, underwent canoni ...[more]