Discontinuation of medications classified as reuptake inhibitors affects treatment response of MDMA-assisted psychotherapy.

ABSTRACT:

Rationale

MDMA-assisted psychotherapy is under investigation as a novel treatment for posttraumatic stress disorder (PTSD). The primary mechanism of action of MDMA involves the same reuptake transporters targeted by antidepressant medications commonly prescribed for PTSD.

Objectives

Data were pooled from four phase 2 trials of MDMA-assisted psychotherapy. To explore the effect of tapering antidepressant medications, participants who had been randomized to receive active doses of MDMA (75-125 mg) were divided into two groups (taper group (n = 16) or non-taper group (n = 34)).

Methods

Between-group comparisons were made for PTSD and depression symptom severity at the baseline and the primary endpoint, and for peak vital signs across two MDMA sessions.

Results

Dem

SUBMITTER: Feduccia AA 

PROVIDER: S-EPMC7826309 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature