Ontology highlight
ABSTRACT:
SUBMITTER: Stirparo GG
PROVIDER: S-EPMC7826362 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Stirparo Giuliano G GG Kurowski Agata A Yanagida Ayaka A Bates Lawrence E LE Strawbridge Stanley E SE Hladkou Siarhei S Stuart Hannah T HT Boroviak Thorsten E TE Silva Jose C R JCR Nichols Jennifer J
Proceedings of the National Academy of Sciences of the United States of America 20210101 3
OCT4 is a fundamental component of the molecular circuitry governing pluripotency in vivo and in vitro. To determine how OCT4 establishes and protects the pluripotent lineage in the embryo, we used comparative single-cell transcriptomics and quantitative immunofluorescence on control and OCT4 null blastocyst inner cell masses at two developmental stages. Surprisingly, activation of most pluripotency-associated transcription factors in the early mouse embryo occurs independently of OCT4, with the ...[more]