The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
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ABSTRACT:
SUBMITTER: Wells CI
PROVIDER: S-EPMC7826789 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
Wells Carrow I CI Al-Ali Hassan H Andrews David M DM Asquith Christopher R M CRM Axtman Alison D AD Dikic Ivan I Ebner Daniel D Ettmayer Peter P Fischer Christian C Frederiksen Mathias M Futrell Robert E RE Gray Nathanael S NS Hatch Stephanie B SB Knapp Stefan S Lücking Ulrich U Michaelides Michael M Mills Caitlin E CE Müller Susanne S Owen Dafydd D Picado Alfredo A Saikatendu Kumar S KS Schröder Martin M Stolz Alexandra A Tellechea Mariana M Turunen Brandon J BJ Vilar Santiago S Wang Jinhua J Zuercher William J WJ Willson Timothy M TM Drewry David H DH
International journal of molecular sciences 20210108 2
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase in ...[more]
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