Ontology highlight
ABSTRACT:
SUBMITTER: Zmievskaya E
PROVIDER: S-EPMC7827151 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Zmievskaya Ekaterina E Valiullina Aygul A Ganeeva Irina I Petukhov Alexey A Rizvanov Albert A Bulatov Emil E
Biomedicines 20210109 1
Adoptive cell transfer (ACT) has long been at the forefront of the battle with cancer that began last century with the therapeutic application of tumor-infiltrating lymphocytes (TILs) against melanoma. The development of novel ACT approaches led researchers and clinicians to highly efficient technologies based on genetically engineered T lymphocytes, with chimeric antigen receptor (CAR)-T cells as the most prominent example. CARs consist of an extracellular domain that represents the single-chai ...[more]