Ontology highlight
ABSTRACT:
SUBMITTER: Musico A
PROVIDER: S-EPMC7827214 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Musicò Angelo A Frigerio Roberto R Mussida Alessandro A Barzon Luisa L Sinigaglia Alessandro A Riccetti Silvia S Gobbi Federico F Piubelli Chiara C Bergamaschi Greta G Chiari Marcella M Gori Alessandro A Cretich Marina M
Vaccines 20210111 1
A workflow for rapid SARS-CoV-2 epitope discovery on peptide microarrays is herein reported. The process started with a proteome-wide screening of immunoreactivity based on the use of a high-density microarray followed by a refinement and validation phase on a restricted panel of probes using microarrays with tailored peptide immobilization through a click-based strategy. Progressively larger, independent cohorts of Covid-19 positive sera were tested in the refinement processes, leading to the i ...[more]