Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida T
PROVIDER: S-EPMC7827354 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Toxins 20210107 1
Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could be proteins, DNA, or antibiotics. However, the mechanism underlying this specificity is poorly understood. Here, we review the substrate recognition mechanism and target residue specificity based on the available complex structures of ARTs and their substrates. We show that the ...[more]