Unknown

Dataset Information

0

Dormant Tumor Cell Vaccination: A Mathematical Model of Immunological Dormancy in Triple-Negative Breast Cancer.


ABSTRACT: Triple-negative breast cancer (TNBC) is a molecular subtype of breast malignancy with a poor clinical prognosis. There is growing evidence that some chemotherapeutic agents induce an adaptive anti-tumor immune response. This reaction has been proposed to maintain the equilibrium phase of the immunoediting process and to control tumor growth by immunological cancer dormancy. We recently reported a model of immunological breast cancer dormancy based on the murine 4T1 TNBC model. Treatment of 4T1 cells in vitro with high-dose chemotherapy activated the type I interferon (type I IFN) signaling pathway, causing a switch from immunosuppressive to cytotoxic T lymphocyte-dependent immune response in vivo, resulting in sustained dormancy. Here, we developed a deterministic mathematical model based on the assumption that two cell subpopulations exist within the treated tumor: one population with high type I IFN signaling and immunogenicity and lower growth rate; the other population with low type I IFN signaling and immunogenicity and higher growth rate. The model reproduced cancer dormancy, elimination, and immune-escape in agreement with our previously reported experimental data. It predicted that the injection of dormant tumor cells with active type I IFN signaling results in complete growth control of the aggressive parental cancer cells injected at a later time point, but also of an already established aggressive tumor. Taken together, our results indicate that a dormant cell population can suppress the growth of an aggressive counterpart by eliciting a cytotoxic T lymphocyte-dependent immune response.

SUBMITTER: Mehdizadeh R 

PROVIDER: S-EPMC7827392 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Dormant Tumor Cell Vaccination: A Mathematical Model of Immunological Dormancy in Triple-Negative Breast Cancer.

Mehdizadeh Reza R   Shariatpanahi Seyed Peyman SP   Goliaei Bahram B   Peyvandi Sanam S   Rüegg Curzio C  

Cancers 20210111 2


Triple-negative breast cancer (TNBC) is a molecular subtype of breast malignancy with a poor clinical prognosis. There is growing evidence that some chemotherapeutic agents induce an adaptive anti-tumor immune response. This reaction has been proposed to maintain the equilibrium phase of the immunoediting process and to control tumor growth by immunological cancer dormancy. We recently reported a model of immunological breast cancer dormancy based on the murine 4T1 TNBC model. Treatment of 4T1 c  ...[more]

Similar Datasets

| S-ECPF-GEOD-37937 | biostudies-other
| S-EPMC8110995 | biostudies-literature
| S-EPMC10605606 | biostudies-literature
| S-EPMC10417082 | biostudies-literature
| S-EPMC8459207 | biostudies-literature
2012-05-11 | E-GEOD-37937 | biostudies-arrayexpress
| S-EPMC9135475 | biostudies-literature
| S-EPMC10499828 | biostudies-literature
| S-EPMC7140497 | biostudies-literature
| S-EPMC5436567 | biostudies-literature