Ontology highlight
ABSTRACT:
SUBMITTER: Plaunt AJ
PROVIDER: S-EPMC7828008 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Plaunt Adam J AJ Islam Sadikul S Macaluso Tony T Gauani Helena H Baker Thomas T Chun Donald D Viramontes Veronica V Chang Christina C Corboz Michel R MR Chapman Richard W RW Li Zhili Z Cipolla David C DC Perkins Walter R WR Malinin Vladimir S VS
International journal of molecular sciences 20210107 2
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has been previously formulated for inhaled administration via a nebulizer. TP demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Here, we report on re-formulation efforts to develop a more convenient solution-based metered-dose inhaler (MDI) formulation of TP, a treprostinil palmitil inhalation aeros ...[more]