Hindering triple negative breast cancer progression by targeting endogenous interleukin-30 requires IFN? signaling.
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ABSTRACT:
SUBMITTER: Sorrentino C
PROVIDER: S-EPMC7828256 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Hindering triple negative breast cancer progression by targeting endogenous interleukin-30 requires IFNγ signaling.
Sorrentino Carlo C Ciummo Stefania Livia SL D'Antonio Luigi L Lanuti Paola P Abrams Scott I SI Yin Zhinan Z Lu Li-Fan LF Di Carlo Emma E
Clinical and translational medicine 20210201 2
IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of endogenous IL30, requires INFγ production by T and NK cells. ...[more]
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