Ontology highlight
ABSTRACT:
SUBMITTER: Schilcher I
PROVIDER: S-EPMC7828365 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Schilcher Irene I Stadler Julia T JT Lechleitner Margarete M Hrzenjak Andelko A Berghold Andrea A Pregartner Gudrun G Lhomme Marie M Holzer Michael M Korbelius Melanie M Reichmann Florian F Springer Anna A Wadsack Christian C Madl Tobias T Kratky Dagmar D Kontush Anatol A Marsche Gunther G Frank Saša S
International journal of molecular sciences 20210113 2
Endothelial lipase (EL) is a strong modulator of the high-density lipoprotein (HDL) structure, composition, and function. Here, we examined the impact of EL on HDL paraoxonase 1 (PON1) content and arylesterase (AE) activity in vitro and in vivo. The incubation of HDL with EL-overexpressing HepG2 cells decreased HDL size, PON1 content, and AE activity. The EL modification of HDL did not diminish the capacity of HDL to associate with PON1 when EL-modified HDL was incubated with PON1-overexpressing ...[more]