Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC7828576 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Molecular biology and evolution 20200701 7
Alternative translation initiation (ATLI) refers to the existence of multiple translation initiation sites per gene and is a widespread phenomenon in eukaryotes. ATLI is commonly assumed to be advantageous through creating proteome diversity or regulating protein synthesis. We here propose an alternative hypothesis that ATLI arises primarily from nonadaptive initiation errors presumably due to the limited ability of ribosomes to distinguish sequence motifs truly signaling translation initiation ...[more]