Ontology highlight
ABSTRACT:
SUBMITTER: Middelburg J
PROVIDER: S-EPMC7829968 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Middelburg Jim J Kemper Kristel K Engelberts Patrick P Labrijn Aran F AF Schuurman Janine J van Hall Thorbald T
Cancers 20210114 2
Immunotherapy of cancer with CD3-bispecific antibodies is an approved therapeutic option for some hematological malignancies and is under clinical investigation for solid cancers. However, the treatment of solid tumors faces more pronounced hurdles, such as increased on-target off-tumor toxicities, sparse T-cell infiltration and impaired T-cell quality due to the presence of an immunosuppressive tumor microenvironment, which affect the safety and limit efficacy of CD3-bispecific antibody therapy ...[more]