Ontology highlight
ABSTRACT:
SUBMITTER: Stauft CB
PROVIDER: S-EPMC7830243 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Stauft Charles B CB Lien Christopher Z CZ Selvaraj Prabhuanand P Liu Shufeng S Wang Tony T TT
Virology 20210125
Dynamic tracking of variant frequencies among viruses circulating in the global pandemic has revealed the emergence and dominance of a D614G mutation in the SARS-CoV-2 spike protein. To address whether pandemic SARS-CoV-2 G614 variant has evolved to become more pathogenic, we infected adult hamsters (>10 months old) with two natural SARS-CoV-2 variants carrying either D614 or G614 spike protein to mimic infection of the adult/elderly human population. Hamsters infected by the two variants exhibi ...[more]