Ontology highlight
ABSTRACT:
SUBMITTER: Claesen K
PROVIDER: S-EPMC7830380 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Claesen Karen K Mertens Joachim C JC Leenaerts Dorien D Hendriks Dirk D
International journal of molecular sciences 20210117 2
Procarboxypeptidase U (proCPU, TAFI, proCPB2) is a basic carboxypeptidase zymogen that is converted by thrombin(-thrombomodulin) or plasmin into the active carboxypeptidase U (CPU, TAFIa, CPB2), a potent attenuator of fibrinolysis. As CPU forms a molecular link between coagulation and fibrinolysis, the development of CPU inhibitors as profibrinolytic agents constitutes an attractive new concept to improve endogenous fibrinolysis or to increase the efficacy of thrombolytic therapy in thromboembol ...[more]