Ontology highlight
ABSTRACT:
SUBMITTER: Poliseno V
PROVIDER: S-EPMC7830597 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Poliseno Viviana V Chaves Sílvia S Brunetti Leonardo L Loiodice Fulvio F Carrieri Antonio A Laghezza Antonio A Tortorella Paolo P Magalhães João D JD Cardoso Sandra M SM Santos M Amélia MA Piemontese Luca L
Biomolecules 20210115 1
Alzheimer's disease (AD) is generally recognized as a multifactorial neurodegenerative pathology with an increasing impact on society. Tenuazonic acid (TA) is a natural compound that was recently identified as a potential multitarget ligand with anti-cholinesterase, anti-amyloidogenic and antioxidant activities. Using its structure as a chemical scaffold, we synthesized and evaluated new derivatives (1-5), including tenuazonic-donepezil (TA-DNP) hybrids (4 and 5) due to the clinical importance o ...[more]