Ontology highlight
ABSTRACT:
SUBMITTER: Rai G
PROVIDER: S-EPMC7830743 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20200927 19
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been recognized as a potential therapeutic target. Thus, potent, selective inhibitors of LDH represent an attractive therapeutic approach. However, to date, pharmacological agents have failed to achieve significant ...[more]