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Four Novel Phenanthrene Derivatives with ?-Glucosidase Inhibitory Activity from Gastrochilus bellinus.

ABSTRACT: Four new phenanthrene derivatives, gastrobellinols A-D (1-4), were isolated from the methanolic extract of Gastrochilus bellinus (Rchb.f.) Kuntze, along with eleven known phenolic compounds including agrostophyllin (5), agrostophyllidin (6), coniferyl aldehyde (7), 4-hydroxybenzaldehyde (8), agrostophyllone (9), gigantol (10), 4-(methoxylmethyl)phenol (11), syringaldehyde (12), 1-(4'-hydroxybenzyl)-imbricartin (13), 6-methoxycoelonin (14), and imbricatin (15). Their structures were determined by spectroscopic methods. Each isolate was evaluated for ?-glucosidase inhibitory activity. Compounds 1, 2, 3, 7, 9, 13, and 15 showed higher activity than the drug acarbose. Gastrobellinol C (3) exhibited the strongest ?-glucosidase inhibition with an IC50 value of 45.92 ?M. A kinetic study of 3 showed competitive inhibition on the ?-glucosidase enzyme. This is the first report on the phytochemical constituents and ?-glucosidase inhibitory activity of G. bellinus.

SUBMITTER: San HT 

PROVIDER: S-EPMC7830893 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Four Novel Phenanthrene Derivatives with <i>α</i>-Glucosidase Inhibitory Activity from <i>Gastrochilus bellinus</i>.

San Htoo Tint HT   Chatsumpun Nutputsorn N   Juengwatanatrakul Thaweesak T   Pornputtapong Natapol N   Likhitwitayawuid Kittisak K   Sritularak Boonchoo B  

Molecules (Basel, Switzerland) 20210114 2

Four new phenanthrene derivatives, gastrobellinols A-D (<b>1-4</b>), were isolated from the methanolic extract of <i>Gastrochilus bellinus</i> (Rchb.f.) Kuntze, along with eleven known phenolic compounds including agrostophyllin (<b>5</b>), agrostophyllidin (<b>6</b>), coniferyl aldehyde (<b>7</b>), 4-hydroxybenzaldehyde (<b>8</b>), agrostophyllone (<b>9</b>), gigantol (<b>10</b>), 4-(methoxylmethyl)phenol (<b>11</b>), syringaldehyde (<b>12</b>), 1-(4'-hydroxybenzyl)-imbricartin (<b>13</b>), 6-m  ...[more]

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