Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.

ABSTRACT: Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed metalloprotease that degrades insulin and several other intermediate-size peptides. For many decades, IDE had been assumed to be involved primarily in hepatic insulin clearance, a key process that regulates availability of circulating insulin levels for peripheral tissues. Emerging evidence, however, suggests that IDE has several other important physiological functions relevant to glucose and insulin homeostasis, including the regulation of insulin secretion from pancreatic β-cells. Investigation of mice with tissue-specific genetic deletion of Ide in the liver and pancreatic β-cells (L-IDE-KO and B-IDE-KO mice, respectively) has revealed additional roles for IDE in the regulation of hepatic insulin acti

SUBMITTER: Gonzalez-Casimiro CM 

PROVIDER: S-EPMC7830943 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature