Ontology highlight
ABSTRACT:
SUBMITTER: El-Chaar NN
PROVIDER: S-EPMC7831112 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
El-Chaar Nader N NN Smith Thomas E TE Shrestha Gajendra G Piccolo Stephen R SR Harper Mary Kay MK Van Wagoner Ryan M RM Lu Zhenyu Z Venancio Ashlee R AR Ireland Chris M CM Bild Andrea H AH Moos Philip J PJ
Marine drugs 20210118 1
Patients diagnosed with basal-like breast cancer suffer from poor prognosis and limited treatment options. There is an urgent need to identify new targets that can benefit patients with basal-like and claudin-low (BL-CL) breast cancers. We screened fractions from our Marine Invertebrate Compound Library (MICL) to identify compounds that specifically target BL-CL breast cancers. We identified a previously unreported trisulfated sterol, i.e., topsentinol L trisulfate (TLT), which exhibited increas ...[more]