Dataset Information

Teaching Missing Data Methodology to Undergraduates Using a Group-Based Project Within a Six-Week Summer Program.

ABSTRACT: Missing data mechanisms, methods of handling missing data, and the potential impact of missing data on study results are usually not taught until graduate school. However, the appropriate handling of missing data is fundamental to biomedical research and should be introduced earlier on in a student's education. The Summer Institute for Training in Biostatistics (SIBS) provides practical experience to motivate trainees to pursue graduate training and biomedical research. Since 2010, SIBS Pittsburgh has demonstrated the feasibility of introducing missing data concepts to trainees in a small-group project-based setting that involves both simulation and data analysis. After learning about missing data mechanisms and statistical techniques, trainees apply what they have learned to a NIDDK/NIH-funded Hepatitis C treatment study, to examine how various hypothesized missing data patterns can affect results. A simulation is also used to examine the bias and precision of these methods under each missing data pattern. Our experience shows that under such project-based training, advanced topics, such as missing data, can be presented to trainees with limited statistical preparation, and ultimately, can further their statistical literacy and reasoning. The tools presented here are provided in the Appendix.

SUBMITTER: Marron MM

PROVIDER: S-EPMC7831542 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Teaching Missing Data Methodology to Undergraduates Using a Group-Based Project Within a Six-Week Summer Program.

Marron Megan M MM Wahed Abdus S AS

Journal of statistics education : an international journal on the teaching and learning of statistics 20160509 1

Missing data mechanisms, methods of handling missing data, and the potential impact of missing data on study results are usually not taught until graduate school. However, the appropriate handling of missing data is fundamental to biomedical research and should be introduced earlier on in a student's education. The Summer Institute for Training in Biostatistics (SIBS) provides practical experience to motivate trainees to pursue graduate training and biomedical research. Since 2010, SIBS Pittsbur ...[more]

PMID: 33500605

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Project description:BackgroundJuvenile idiopathic arthritis (JIA), among the most common chronic diseases of childhood, can be associated with attenuated physical activity levels, reduced fitness, decreased functionality and pain. This pilot study aimed to determine the safety, feasibility and effect of a six week resistance training program in children with JIA.MethodsYouth (8-18 years) with JIA participated in a home-based resistance training program. Participants reported pain on an electronic diary once a day for one week prior to training, then once a day on non-exercise days and three times a day (before-exercise, after-exercise, and end-of-day) on exercise days for the subsequent six weeks of training. Secondary outcome measures included inflammation (assessed by ultrasound), muscle size (assessed by ultrasound), muscle strength (assessed by dynamometer) and functional ability (assessed by childhood health assessment questionnaire), measured at baseline and post-training. Participants were also instructed to wear an accelerometer one week prior to training to estimate baseline physical activity levels. Statistical analyses included safety (pain changes and any adverse events), feasibility (adherence to program and modifications made to exercises) and effect of program (differences in secondary measures pre and post training). An alpha level of p?<?0.05 was accepted as significant.ResultsSeven participants completed an average of 12.7?±?3.4 (range 8-17) exercise sessions out of a possible 18 (70.6%). No adverse events were reported and pain did not increase over the seven weeks. Secondary measures revealed a significant increase in vastus lateralis thickness from pre to post training (p?<?0.05). End-of-day pain intensity was correlated to end-of-day stiffness, fatigue and mood (r?=?.864, r?=?.581, r?=?-.637, respectively, p?<?0.001). Pain intensity was also correlated with ratings of perceived exertion of the exercise (r?=?0.324, p?<?0.01). Only two children met the recommended 60 minutes of moderate to vigorous physical activity per day.ConclusionsA six week home-based resistance training program is both safe (absence of pain changes or adverse events over the six weeks) and feasible (comparable adherence rates to other exercise studies involving JIA and individually modifiable) in children with JIA.

Dataset Information

Teaching Missing Data Methodology to Undergraduates Using a Group-Based Project Within a Six-Week Summer Program.

Publications

Teaching Missing Data Methodology to Undergraduates Using a Group-Based Project Within a Six-Week Summer Program.

Similar Datasets

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