Dataset Information

Hypertension is a clinically important risk factor for critical illness and mortality in COVID-19: A meta-analysis.

ABSTRACT:

Aims

As reported, hypertension may play an important role in adverse outcomes of coronavirus disease-2019 (COVID-19), but it still had many confounding factors. The aim of this study was to explore whether hypertension is an independent risk factor for critical COVID-19 and mortality.

Data synthesis

The Medline, PubMed, Embase, and Web of Science databases were systematically searched until November 2020. Combined odds ratios (ORs) with their 95% confidence interval (CIs) were calculated by using random-effect models, and the effect of covariates was analyzed using the subgroup analysis and meta-regression analysis. A total of 24 observational studies with 99,918 COVID-19 patients were included in the meta-analysis. The proportions of hypertension in critical COVID-19 were 37% (95% CI: 0.27 -0.47) when compared with 18% (95% CI: 0.14 -0.23) of noncritical COVID-19 patients, in those who died were 46% (95%CI: 0.37 -0.55) when compared with 22% (95% CI: 0.16 -0.28) of survivors. Pooled results based on the adjusted OR showed that patients with hypertension had a 1.82-fold higher risk for critical COVID-19 (aOR: 1.82; 95% CI: 1.19 - 2.77; P = 0.005) and a 2.17-fold higher risk for COVID-19 mortality (aOR: 2.17; 95% CI: 1.67 - 2.82; P < 0.001). Subgroup analysis results showed that male patients had a higher risk of developing to the critical condition than female patients (OR: 3.04; 95%CI: 2.06 - 4.49; P < 0.001) and age >60 years was associated with a significantly increased risk of COVID-19 mortality (OR: 3.12; 95% CI: 1.93 - 5.05; P < 0.001). Meta-regression analysis results also showed that age (Coef. = 2.3×10^-2, P = 0.048) had a significant influence on the association between hypertension and COVID-19 mortality.

Conclusions

Evidence from this meta-analysis suggested that hypertension was independently associated with a significantly increased risk of critical COVID-19 and inhospital mortality of COVID-19.

SUBMITTER: Du Y

PROVIDER: S-EPMC7831720 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Hypertension is a clinically important risk factor for critical illness and mortality in COVID-19: A meta-analysis.

Du Yanbin Y Zhou Nan N Zha Wenting W Lv Yuan Y

Nutrition, metabolism, and cardiovascular diseases : NMCD 20201211 3

<h4>Aims</h4>As reported, hypertension may play an important role in adverse outcomes of coronavirus disease-2019 (COVID-19), but it still had many confounding factors. The aim of this study was to explore whether hypertension is an independent risk factor for critical COVID-19 and mortality.<h4>Data synthesis</h4>The Medline, PubMed, Embase, and Web of Science databases were systematically searched until November 2020. Combined odds ratios (ORs) with their 95% confidence interval (CIs) were cal ...[more]

PMID: 33549450

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Dataset Information

Hypertension is a clinically important risk factor for critical illness and mortality in COVID-19: A meta-analysis.

Aims

Data synthesis

Conclusions

Publications

Hypertension is a clinically important risk factor for critical illness and mortality in COVID-19: A meta-analysis.

Similar Datasets

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