Dataset Information

Retrospective study identifies infection related risk factors in close contacts during COVID-19 epidemic.

ABSTRACT:

Objectives

This study aimed to compare the risk of infection of children with that of adults and to explore risk factors of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by following up close contacts of COVID-19 patients.

Method

The retrospective cohort study was performed among close contacts of index cases diagnosed with COVID-19 in Guangzhou, China. Demographic characteristics, clinical symptoms and exposure information were extracted. Logistic regression analysis was employed to explore the risk factors. The restricted cubic spline was conducted to examine to the dose-response relationship between age and SARS-CoV-2 infection.

Results

The secondary attack rate (SAR) was 4.4% in 1,344 close contacts. The group of household contacts (17.2%) had the highest SAR. The rare-frequency contact (p < 0.001) and moderate-frequency contact (p < 0.001) were associated with lower risk of infection. Exposure to index cases with dry cough symptoms was associated with infection in close contacts (p = 0.004). Compared with children, adults had a significantly increased risk of infection (p = 0.014). There is a linear positive correlation between age and infection (p = 0.001).

Conclusions

Children are probably less susceptible to COVID-19. Close contacts with frequent contact with patients and those exposed to patients with cough symptoms are associated with an increased risk of infection.

SUBMITTER: Hu P

PROVIDER: S-EPMC7832759 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Retrospective study identifies infection related risk factors in close contacts during COVID-19 epidemic.

Hu Peipei P Ma Mengmeng M Jing Qinlong Q Ma Yu Y Gan Lin L Chen Yan Y Liu Jundi J Wang Dahu D Zhang Zhoubin Z Zhang Dingmei D

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20201210

<h4>Objectives</h4>This study aimed to compare the risk of infection of children with that of adults and to explore risk factors of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by following up close contacts of COVID-19 patients.<h4>Method</h4>The retrospective cohort study was performed among close contacts of index cases diagnosed with COVID-19 in Guangzhou, China. Demographic characteristics, clinical symptoms and exposure information were extracted. Logistic re ...[more]

PMID: 33310026

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Dataset Information

Retrospective study identifies infection related risk factors in close contacts during COVID-19 epidemic.

Objectives

Method

Results

Conclusions

Publications

Retrospective study identifies infection related risk factors in close contacts during COVID-19 epidemic.

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