Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC7833309 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Genomics 20201228 2
T-cell receptor (TCR) is crucial in T cell-mediated virus clearance. To date, TCR bias has been observed in various diseases. However, studies on the TCR repertoire of COVID-19 patients are lacking. Here, we used single-cell V(D)J sequencing to conduct comparative analyses of TCR repertoire between 12 COVID-19 patients and 6 healthy controls, as well as other virus-infected samples. We observed distinct T cell clonal expansion in COVID-19. Further analysis of VJ gene combination revealed 6 VJ pa ...[more]