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Pathogenesis of COVID-19 and the quality control of nucleic acid detection.

ABSTRACT: The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid laboratory diagnosis, treatment assessment, epidemic prevention and control of COVID-19. However, since COVID-19 is caused by a new emerging virus and NAT for COVID-19 has not been clinically applied before, false negative results inconsistent with clinical diagnosis have appeared in clinical practice. Therefore, it is urgent to improve the sensitivity of NAT for COVID-19. This study aimed to summarize the current situation and prospect of NAT based on the latest findings on COVID-19 infection. Also, the quality control of sample collection was discussed. Hopefully, this study could help to improve the effectiveness of NAT for COVID-19.

SUBMITTER: Mao XD

PROVIDER: S-EPMC7833324 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Pathogenesis of COVID-19 and the quality control of nucleic acid detection.

Mao Xiao-Dong XD Li Taiping T Xu Zhirong Z Liu Kangsheng K

Biochemical and biophysical research communications 20210101

The new coronavirus pneumonia (COVID-19) epidemic spread rapidly throughout the world. Considering the strong infectivity and clustering of COVID-19, early detection of infectious cases is of great significance to control the epidemic. Nucleic acid testing (NAT) plays an important role in rapid laboratory diagnosis, treatment assessment, epidemic prevention and control of COVID-19. However, since COVID-19 is caused by a new emerging virus and NAT for COVID-19 has not been clinically applied befo ...[more]

PMID: 33581843

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