Ontology highlight
ABSTRACT:
SUBMITTER: Wang CY
PROVIDER: S-EPMC7834050 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wang Chin-Yu CY Lin Bai-Ling BL Chen Chung-Hsuan CH
Cancer biology & therapy 20201129 1
We developed a DNA aptamer, Ap52, against the shared tumor-specific MAGE-A3<sub>111-125</sub> peptide antigen that was used to target multiple types of cancer cells. Here we report the <i>in vivo</i> study of mice implanted with pancreatic tumor cells AsPC-1, which demonstrates accumulation of phosphorothioate-modified Ap52 (ThioAp52) at the xenograft tumor following either intravenous or <i>in situ</i> injection. When complexed with antitumor drug doxorubicin (Dox), ThioAp52 achieves targeted d ...[more]