Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC7834164 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Liu Jian J Zhai You Y Liang Lijun L Zhu Danyan D Zhao Qingwei Q Qiu Yunqing Y
Chemical physics 20201211
Coronavirus disease 2019 (COVID-19) has caused more than 840,000 deaths as of 31 August 2020 in the whole world. The COVID-19 main protease (M<sup>pro</sup>) has been validated as an attractive target for drug design. In this work, the binding mechanisms of five protease inhibitors (e.g., danoprevir, darunavir, ASC09, lopinavir and ritonavir) to COVID-19 M<sup>pro</sup> were investigated. Based on the docking score, five protease inhibitors structures were selected for further evaluation. It is ...[more]