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COVID-19: Pharmacology and kinetics of viral clearance.

ABSTRACT: Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional studies. However, results from high-quality trials are scarce. Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients.

SUBMITTER: Farina N

PROVIDER: S-EPMC7834389 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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COVID-19: Pharmacology and kinetics of viral clearance.

Farina Nicola N Ramirez Giuseppe A GA De Lorenzo Rebecca R Di Filippo Luigi L Conte Caterina C Ciceri Fabio F Manfredi Angelo A AA Rovere-Querini Patrizia P

Pharmacological research 20200803

Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional ...[more]

PMID: 32758635

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