Ontology highlight
ABSTRACT:
SUBMITTER: Scagnolari C
PROVIDER: S-EPMC7834390 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Virus research 20210105
The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Hetero ...[more]