Unknown

Dataset Information

0

Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).


ABSTRACT: The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.

SUBMITTER: Scagnolari C 

PROVIDER: S-EPMC7834390 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications


The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Hetero  ...[more]

Similar Datasets

| S-EPMC8141987 | biostudies-literature
| S-EPMC7454839 | biostudies-literature
| S-EPMC8083502 | biostudies-literature
| PRJNA309093 | ENA
| PRJNA401637 | ENA
| PRJNA279427 | ENA
| PRJNA396214 | ENA
| PRJNA208586 | ENA
| PRJNA209575 | ENA