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Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).

ABSTRACT: The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.

SUBMITTER: Scagnolari C

PROVIDER: S-EPMC7834390 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).

Scagnolari Carolina C Pierangeli Alessandra A Frasca Federica F Bitossi Camilla C Viscido Agnese A Oliveto Giuseppe G Scordio Mirko M Mazzuti Laura L Di Carlo Daniele D Gentile Massimo M Solimini Angelo A Ceccarelli Giancarlo G Pugliese Francesco F Mastroianni Claudio Maria CM d'Ettorre Gabriella G Turriziani Ombretta O Antonelli Guido G

Virus research 20210105

The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Hetero ...[more]

PMID: 33418027

Dataset Information

Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).

Publications

Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).

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