Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
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ABSTRACT:
SUBMITTER: Brouwer PJM
PROVIDER: S-EPMC7834972 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Study show that modified vaccinia Ankara (MVA)-based COVID-19 vaccine expressing membrane anchored pre-fusion stabilized spike (MVA/S) induces both neutralizing antibodies and CD8+ T cells in the blood and lung and protects from SARS-CoV-2 challenge. Single-cell RNA sequencing analysis of lung cells at day 4 post-infection revealed that MVA/S vaccination also protected macaques from infection-induced inflammation and B cell abnormalities, and lowered induction of interferon stimulated genes.
2021-02-01 | GSE165747 | GEO