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Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.

ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.

SUBMITTER: Brouwer PJM 

PROVIDER: S-EPMC7834972 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.

Brouwer Philip J M PJM   Brinkkemper Mitch M   Maisonnasse Pauline P   Dereuddre-Bosquet Nathalie N   Grobben Marloes M   Claireaux Mathieu M   de Gast Marlon M   Marlin Romain R   Chesnais Virginie V   Diry Ségolène S   Allen Joel D JD   Watanabe Yasunori Y   Giezen Julia M JM   Kerster Gius G   Turner Hannah L HL   van der Straten Karlijn K   van der Linden Cynthia A CA   Aldon Yoann Y   Naninck Thibaut T   Bontjer Ilja I   Burger Judith A JA   Poniman Meliawati M   Mykytyn Anna Z AZ   Okba Nisreen M A NMA   Schermer Edith E EE   van Breemen Marielle J MJ   Ravichandran Rashmi R   Caniels Tom G TG   van Schooten Jelle J   Kahlaoui Nidhal N   Contreras Vanessa V   Lemaître Julien J   Chapon Catherine C   Fang Raphaël Ho Tsong RHT   Villaudy Julien J   Sliepen Kwinten K   van der Velden Yme U YU   Haagmans Bart L BL   de Bree Godelieve J GJ   Ginoux Eric E   Ward Andrew B AB   Crispin Max M   King Neil P NP   van der Werf Sylvie S   van Gils Marit J MJ   Le Grand Roger R   Sanders Rogier W RW  

Cell 20210126 5

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits,  ...[more]

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