Dataset Information

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

ABSTRACT:

Purpose

Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN.

Methods

We conducted a case-control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured questionnaire included 84 queries on socio-demographic, behavioral, dietary and clinical information.

Results

Increased risk was associated with history of cancer ("other tumor", lung OR?=?7.18; 95% CI: 2.55-20.20 and pancreas OR?=?5.88; 95% CI: 2.43-14.22; "family history of tumor", lung OR?=?2.66; 95% CI: 1.53-4.64 and pancreas OR?=?1.94; 95% CI: 1.19-3.17; "family history of lung tumor", lung OR?=?2.56; 95% CI: 1.05-6.24 and pancreas OR?=?2.60; 95% CI: 1.13-5.95). Type 2 diabetes mellitus associated with an increased risk of pancreatic NEN (OR?=?3.01; 95% CI: 1.15-7.89).

Conclusions

Besides site-specific risk factors, there is a significant link between neuroendocrine neoplasia and cancer in general, pointing to a shared cancer predisposition.

SUBMITTER: Giraldi L

PROVIDER: S-EPMC7835148 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Giraldi Luca L Vecchioni Alessia A Carioli Greta G Bilotta Mirna M La Rosa Stefano S Imperatori Andrea A Volante Marco M Brizzi Maria Pia MP Inzani Frediano F Petrone Gianluigi G Schinzari Giovanni G Bianchi Antonio A Margaritora Stefano S Alfieri Sergio S La Vecchia Carlo C Boccia Stefania S Rindi Guido G

Endocrine 20200831 1

<h4>Purpose</h4>Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN.<h4>Methods</h4>We conducted a case-control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured ques ...[more]

PMID: 32869113

Similar Datasets

Project description:BackgroundInfection is the leading cause of short-term mortality after lung transplantation. This study aimed to investigate the epidemiology and risk factors of infection in Chinese lung transplant recipients.MethodsA total of 107 lung transplant patients from 2016 to 2020 were included in this study. The basic data of patients were collected, combined with clinically relevant physiological and biochemical indicators and laboratory test results. Transplant patients with new infections 48 hours after surgery were included in the infected group, and the rest were in the Uninfected group. The risk factors of postoperative infection were analyzed between the two groups.ResultsA total of 107 patients were included in the study, including 89 males and 18 females. All patients underwent lung transplantation. A total of 80 patients (74.8%) experienced a postoperative infection. Pathogenic microorganisms were found in 136 samples, predominantly in the sputum (n=120 samples; 88.2%). We detected 107 strains of Gram-negative bacteria (78.7%), including 30 strains of Acinetobacter baumannii (22.1%) and 27 strains of Klebsiella pneumoniae (19.9%); 18 strains of Gram-positive bacteria (13.2%), including 11 strains of Staphylococcus haemolyticus (8.1%) and 2 strains of Enterococcus faecium (1.5%); and 11 strains (8.1%) were infected by fungi. There were 87 strains of multidrug-resistant bacteria. The main multidrug-resistant bacteria included 28 strains of Acinetobacter baumannii (32.2%) and 25 strains of Klebsiella pneumoniae (28.7%). Multivariate analysis showed that ventilator use over 3 days was an independent risk factor for postoperative infection [odds ratio (OR): 4.94, 95% confidence interval (CI): 1.31 to 18.66, P=0.019].ConclusionsThe infection rate after lung transplantation in our hospital is similar to that of other lung transplantation studies, but higher than that following transplantation of other organs. The pathogens of postoperative infection were similar to those identified in other lung transplantation studies. Using a ventilator for more than 3 days is a risk factor for postoperative infection, suggesting that preventive measures for postoperative infection should be taken in such patients, and early postoperative discontinuation of the ventilator may reduce postoperative infection.

Project description:IntroductionMixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare form of neuroendocrine neoplasms (NENs). The purpose of this study was to investigate the characteristics and survival profile of appendiceal MiNENs, with a view of providing robust clinical features of this rare disease.MethodsPatients were selected from the Surveillance, Epidemiology, and End Results database (2004-2016). The prognosis of MiNEN (n = 315) was compared with other histological subtypes including neuroendocrine tumor (NETs) (n = 1734), neuroendocrine carcinoma (NECs) (n = 375), goblet cell carcinoid (GCC) (n = 968), signet ring cell carcinoma (n = 463), mucinous adenocarcinoma (MAC) (n = 2355), and non-mucinous adenocarcinoma (NMAC) (n = 1187) in the appendix. Age-adjusted incidence was calculated using Joinpoint regression. The Cox proportional hazards model and the Fine-Gray competing risk model were used to perform overall survival (OS) and cancer-specific mortality (CSM) analyses, respectively.ResultsThe age-adjusted incidence of MiNENs increased from 0.01/100,000 person-years in 2004 to 0.07/100,000 person-years in 2016. The 3-, 5-, and 10-year OS rates for MiNENs were 69.5, 57.4, and 43.7%, respectively, and the corresponding CSM rates were 23.1, 36.4, and 45.1%, respectively. Multivariate analysis revealed that the prognosis of MiNENs was worse than that of NETs, NECs, GCC, and MAC but better than that of NMAC and signet ring cell carcinoma. Tumor extension was the only independent factor influencing the prognosis of MiNENs, but tumor size, grade, and surgical approaches were not. Moreover, when compared with local excision or appendectomy, extensive surgery such as hemicolectomy or colectomy did not prolong the survival of individuals with MiNENs.ConclusionMiNEN is a rare but aggressive tumor with a poor prognosis differing from NENs, GCC and adenocarcinomas. To improve the prognosis of the disease, early diagnosis and comprehensive evaluation are necessary.

Dataset Information

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Purpose

Methods

Results

Conclusions

Publications

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets