Dataset Information

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

ABSTRACT:

Purpose

Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN.

Methods

We conducted a case-control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured questionnaire included 84 queries on socio-demographic, behavioral, dietary and clinical information.

Results

Increased risk was associated with history of cancer ("other tumor", lung OR?=?7.18; 95% CI: 2.55-20.20 and pancreas OR?=?5.88; 95% CI: 2.43-14.22; "family history of tumor", lung OR?=?2.66; 95% CI: 1.53-4.64 and pancreas OR?=?1.94; 95% CI: 1.19-3.17; "family history of lung tumor", lung OR?=?2.56; 95% CI: 1.05-6.24 and pancreas OR?=?2.60; 95% CI: 1.13-5.95). Type 2 diabetes mellitus associated with an increased risk of pancreatic NEN (OR?=?3.01; 95% CI: 1.15-7.89).

Conclusions

Besides site-specific risk factors, there is a significant link between neuroendocrine neoplasia and cancer in general, pointing to a shared cancer predisposition.

SUBMITTER: Giraldi L

PROVIDER: S-EPMC7835148 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Giraldi Luca L Vecchioni Alessia A Carioli Greta G Bilotta Mirna M La Rosa Stefano S Imperatori Andrea A Volante Marco M Brizzi Maria Pia MP Inzani Frediano F Petrone Gianluigi G Schinzari Giovanni G Bianchi Antonio A Margaritora Stefano S Alfieri Sergio S La Vecchia Carlo C Boccia Stefania S Rindi Guido G

Endocrine 20200831 1

<h4>Purpose</h4>Neuroendocrine neoplasia (NEN) has been displaying an incremental trend along the last two decades. This phenomenon is poorly understood, and little information is available on risk factor for neuroendocrine neoplasia development. Aim of this work is to elucidate the role of potentially modifiable risk factors for pancreatic and pulmonary NEN.<h4>Methods</h4>We conducted a case-control study on 184 patients with NEN (100 pancreas and 84 lung) and 248 controls. The structured ques ...[more]

PMID: 32869113

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Project description:IntroductionMixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare form of neuroendocrine neoplasms (NENs). The purpose of this study was to investigate the characteristics and survival profile of appendiceal MiNENs, with a view of providing robust clinical features of this rare disease.MethodsPatients were selected from the Surveillance, Epidemiology, and End Results database (2004-2016). The prognosis of MiNEN (n = 315) was compared with other histological subtypes including neuroendocrine tumor (NETs) (n = 1734), neuroendocrine carcinoma (NECs) (n = 375), goblet cell carcinoid (GCC) (n = 968), signet ring cell carcinoma (n = 463), mucinous adenocarcinoma (MAC) (n = 2355), and non-mucinous adenocarcinoma (NMAC) (n = 1187) in the appendix. Age-adjusted incidence was calculated using Joinpoint regression. The Cox proportional hazards model and the Fine-Gray competing risk model were used to perform overall survival (OS) and cancer-specific mortality (CSM) analyses, respectively.ResultsThe age-adjusted incidence of MiNENs increased from 0.01/100,000 person-years in 2004 to 0.07/100,000 person-years in 2016. The 3-, 5-, and 10-year OS rates for MiNENs were 69.5, 57.4, and 43.7%, respectively, and the corresponding CSM rates were 23.1, 36.4, and 45.1%, respectively. Multivariate analysis revealed that the prognosis of MiNENs was worse than that of NETs, NECs, GCC, and MAC but better than that of NMAC and signet ring cell carcinoma. Tumor extension was the only independent factor influencing the prognosis of MiNENs, but tumor size, grade, and surgical approaches were not. Moreover, when compared with local excision or appendectomy, extensive surgery such as hemicolectomy or colectomy did not prolong the survival of individuals with MiNENs.ConclusionMiNEN is a rare but aggressive tumor with a poor prognosis differing from NENs, GCC and adenocarcinomas. To improve the prognosis of the disease, early diagnosis and comprehensive evaluation are necessary.

Dataset Information

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Purpose

Methods

Results

Conclusions

Publications

Risk factors for pancreas and lung neuroendocrine neoplasms: a case-control study.

Similar Datasets

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