Dataset Information
GC-MS/MS analysis of metabolites derived from a single human blastocyst.
Ontology highlight
ABSTRACT: Introduction
The field of assisted reproductive technology (ART) has significantly advanced; however, morphological evaluation remains as the chosen method of assessment of embryo quality.Objective
We aimed to examine metabolic changes in embryo culture medium to develop a non-invasive method for evaluation of embryo quality.Methods
We performed metabolic analysis of culture medium obtained from a single blastocyst cultured for freezing.Results
In total, 187 (39.8%) of the 469 detectable organic acid metabolites were identified. A significant change (p?ConclusionThe quantification of metabolism in human embryos may assist in identification and selection of good-quality embryos with high rates of survival before freezing and implantation in conjunction with morphological classification. This may help to identify embryos with high rates of survival.
SUBMITTER: Inoue N
PROVIDER: S-EPMC7835178 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
GC-MS/MS analysis of metabolites derived from a single human blastocyst.
Metabolomics : Official journal of the Metabolomic Society 20210125 2
<h4>Introduction</h4>The field of assisted reproductive technology (ART) has significantly advanced; however, morphological evaluation remains as the chosen method of assessment of embryo quality.<h4>Objective</h4>We aimed to examine metabolic changes in embryo culture medium to develop a non-invasive method for evaluation of embryo quality.<h4>Methods</h4>We performed metabolic analysis of culture medium obtained from a single blastocyst cultured for freezing.<h4>Results</h4>In total, 187 (39.8 ...[more]