Dataset Information

GC-MS/MS analysis of metabolites derived from a single human blastocyst.

ABSTRACT:

Introduction

The field of assisted reproductive technology (ART) has significantly advanced; however, morphological evaluation remains as the chosen method of assessment of embryo quality.

Objective

We aimed to examine metabolic changes in embryo culture medium to develop a non-invasive method for evaluation of embryo quality.

Methods

We performed metabolic analysis of culture medium obtained from a single blastocyst cultured for freezing.

Results

In total, 187 (39.8%) of the 469 detectable organic acid metabolites were identified. A significant change (p?ConclusionThe quantification of metabolism in human embryos may assist in identification and selection of good-quality embryos with high rates of survival before freezing and implantation in conjunction with morphological classification. This may help to identify embryos with high rates of survival.

SUBMITTER: Inoue N

PROVIDER: S-EPMC7835178 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

GC-MS/MS analysis of metabolites derived from a single human blastocyst.

Inoue Naomi N Nishida Yoshihiro Y Harada Emi E Sakai Kumiko K Narahara Hisashi H

Metabolomics : Official journal of the Metabolomic Society 20210125 2

<h4>Introduction</h4>The field of assisted reproductive technology (ART) has significantly advanced; however, morphological evaluation remains as the chosen method of assessment of embryo quality.<h4>Objective</h4>We aimed to examine metabolic changes in embryo culture medium to develop a non-invasive method for evaluation of embryo quality.<h4>Methods</h4>We performed metabolic analysis of culture medium obtained from a single blastocyst cultured for freezing.<h4>Results</h4>In total, 187 (39.8 ...[more]

PMID: 33495963

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Dataset Information

GC-MS/MS analysis of metabolites derived from a single human blastocyst.

Introduction

Objective

Methods

Results

Publications

GC-MS/MS analysis of metabolites derived from a single human blastocyst.

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